Periodontal pathogenesis periodontitis is a chronic multifactorial disease characterized by an inflammation of the periodontal tissue mediated by the host which is associated with dysbiotic plaque biofilms resulting in the progressive destruction of the tooth supporting apparatus and loss of periodontal attachment 1 10 . Understanding of molecular interactions between oral pathogens or their products with host would lead to the future development of therapeutic strategies such as vaccines for periodontitis towards this goal we developed genetic systems in non pathogenic oral streptococci streptococci gordonii for expression and delivery of vaccine antigens. Molecular pathogenesis of periodontal disease the molecular era has unraveled aspects of genetics epigenetics lifestyle and environmental factors that in combination influence biofilm composition and the hosts inflammatory immune response creating a heterogenic biological phenotype that we label as periodontitis molecular aspects of the pathogenesis of periodontitis it is believed . Nowadays a growing body of literature has accumulated to investigate the association between bone diseases periodontal pathogens and periodontal diseases the integration of pathogen associated molecular patterns from microorganisms with their surface receptors in the immune cells induces the production of several cytokines and chemokines that present either a pro and or anti inflammatory role and the activation of mechanisms of controlling this and the related disease such as
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